tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate

Base Information

Chemical Name:tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate
CAS No.:1420532-39-3
Molecular Formula:C₂₄H₂₈F₃N₃O₄
Molecular Weight:479.499
Hs Code.:

Synonyms:tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate

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Chemical Property of tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate

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Technology Process of tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate

There total 7 articles about tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219936-26-1
N-ethyl-N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

: 1318629-68-3
N-(2-bromo-5-formyl-1H-pyrrol-1-yl)-carbamic acid tert-butyl ester

: 1420532-39-3
tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 937046-95-2
N-(1H-pyrrol-1-yl)-carbamic acid tert-butyl ester

: 1420532-39-3
tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

2.1: TurboGrignard / 1,4-dioxane / 5 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With N-Bromosuccinimide; TurboGrignard; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1138822-07-7
N-(2,5-dibromo-1H-pyrrol-1-yl)-carbamic acid tert-butyl ester

: 1420532-39-3
tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TurboGrignard / 1,4-dioxane / 5 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With TurboGrignard; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane;