?N-ethyl-N-[2-(2-methylpyrrolo[1,2-b]pyridazin-7-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Base Information

Chemical Name:?N-ethyl-N-[2-(2-methylpyrrolo[1,2-b]pyridazin-7-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide
CAS No.:1420532-41-7
Molecular Formula:C₂₂H₂₂F₃N₃O
Molecular Weight:401.431
Hs Code.:

Synonyms:?N-ethyl-N-[2-(2-methylpyrrolo[1,2-b]pyridazin-7-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

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Chemical Property of ?N-ethyl-N-[2-(2-methylpyrrolo[1,2-b]pyridazin-7-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

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Technology Process of ?N-ethyl-N-[2-(2-methylpyrrolo[1,2-b]pyridazin-7-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

There total 7 articles about ?N-ethyl-N-[2-(2-methylpyrrolo[1,2-b]pyridazin-7-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1420532-40-6
tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate

: 1420532-41-7
?N-ethyl-N-[2-(2-methylpyrrolo[1,2-b]pyridazin-7-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 70 ℃; for 3h; Sealed tube;

Reference yield:

: 1318629-68-3
N-(2-bromo-5-formyl-1H-pyrrol-1-yl)-carbamic acid tert-butyl ester

: 1420532-41-7
?N-ethyl-N-[2-(2-methylpyrrolo[1,2-b]pyridazin-7-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran / 15 h / 50 °C / Sealed tube

3: hydrogenchloride / 1,4-dioxane; water / 3 h / 70 °C / Sealed tube

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1420532-39-3
tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate

: 1420532-41-7
?N-ethyl-N-[2-(2-methylpyrrolo[1,2-b]pyridazin-7-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran / 15 h / 50 °C / Sealed tube

2: hydrogenchloride / 1,4-dioxane; water / 3 h / 70 °C / Sealed tube

With hydrogenchloride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water;