tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate

Base Information

Chemical Name:tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate
CAS No.:1420532-40-6
Molecular Formula:C₂₇H₃₂F₃N₃O₄
Molecular Weight:519.564
Hs Code.:

Synonyms:tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate

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Chemical Property of tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate

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Technology Process of tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate

There total 10 articles about tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4202-14-6
dimethyl (2-oxopropyl)phosphonate

: 1420532-39-3
tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-formyl-1H-pyrrol-1-yl}carbamate

: 1420532-40-6
tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 50 ℃; for 15h; Sealed tube;

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 1420532-40-6
tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1-methyl-pyrrolidin-2-one / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

3.1: TurboGrignard / 1,4-dioxane / 5 h / 0 - 20 °C

3.2: 0 - 20 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

5.1: potassium carbonate / tetrahydrofuran / 15 h / 50 °C / Sealed tube

With hydrogenchloride; N-Bromosuccinimide; TurboGrignard; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one;

Reference yield:

: 937046-95-2
N-(1H-pyrrol-1-yl)-carbamic acid tert-butyl ester

: 1420532-40-6
tert-butyl {2-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-5-[(1E)-3-oxobut-1-en-1-yl]-1H-pyrrol-1-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

2.1: TurboGrignard / 1,4-dioxane / 5 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

4.1: potassium carbonate / tetrahydrofuran / 15 h / 50 °C / Sealed tube

With N-Bromosuccinimide; TurboGrignard; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane;