C₅₉H₆₉NO₁₅Si

Base Information

• Chemical Name: C₅₉H₆₉NO₁₅Si
• CAS No.: 260249-49-8
• Molecular Formula: C₅₉H₆₉NO₁₅Si
• Molecular Weight: 1060.28
• Mol file: 260249-49-8.mol

Synonyms:C₅₉H₆₉NO₁₅Si

Chemical Property of C₅₉H₆₉NO₁₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₉H₆₉NO₁₅Si

There total 8 articles about C₅₉H₆₉NO₁₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C59H67NO15Si → C59H69NO15Si (260249-49-8)

Guidance literature:

With sodium cyanoborohydride; In acetic acid;

DOI:10.1016/S0040-4039(99)02056-0

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) → C59H69NO15Si (260249-49-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / pyridine / 3 h / 20 °C

2: TsN₃; Et₃N; DBU / acetonitrile / 16 h / 20 °C

3: 80 percent / Cu(acac)2 / 70 h / 60 °C

4: ([Bu]2Sn(Cl))2O / ethanol / 24 h / Heating

5: 90 percent

6: 73 percent / NaBH₃CN / acetic acid

With copper acetylacetonate; 4-toluenesulfonyl azide; 1,3-dichlorotetrabutyldistannoxane; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In pyridine; ethanol; acetic acid; acetonitrile; 1: Condensation / 2: Diazotization / 3: Substitution / 4: transesterification / 5: Swern oxid. / 6: Reduction;

DOI:10.1016/S0040-4039(99)02056-0

Reference yield:

C52H62O14Si (260245-86-1) → C59H69NO15Si (260249-49-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 100 percent / pyridine / 3 h / 20 °C

2: TsN₃; Et₃N; DBU / acetonitrile / 16 h / 20 °C

3: 80 percent / Cu(acac)2 / 70 h / 60 °C

4: ([Bu]2Sn(Cl))2O / ethanol / 24 h / Heating

5: 90 percent

6: 73 percent / NaBH₃CN / acetic acid

With copper acetylacetonate; 4-toluenesulfonyl azide; 1,3-dichlorotetrabutyldistannoxane; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In pyridine; ethanol; acetic acid; acetonitrile; 1: Condensation / 2: Diazotization / 3: Substitution / 4: transesterification / 5: Swern oxid. / 6: Reduction;

DOI:10.1016/S0040-4039(99)02056-0

upstream raw materials:

C₆₁H₇₁NO₁₆Si

O-benzylhydoxylamine hydrochloride

C₅₂H₆₂O₁₄Si

C₅₉H₆₉NO₁₄Si

Downstream raw materials:

C₄₄H₅₉NO₁₂Si

taxol

7-(triethylsilyl)-13-O-[((4S,5R)-2,4-diphenyl-4,5-dihydrooxazol-5-yl)carbonyl]baccatin

C₅₁H₆₁NO₁₂Si

Refernces