1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one

Base Information

• Chemical Name: 1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one
• CAS No.: 882512-66-5
• Molecular Formula: C₁₆H₂₂O₃
• Molecular Weight: 262.349
• Mol file: 882512-66-5.mol

Synonyms:1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one

Chemical Property of 1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one

There total 13 articles about 1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-ol (882512-67-6) → 1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one (882512-66-5)

Guidance literature:

With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2006.01.021

Reference yield:

1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-one (882512-69-8) + allyl bromide (106-95-6) → 1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one (882512-66-5) + 1-(1-allyloxy-2-methyl-propenyl)-2,3-dimethoxy-5-methyl-benzene

Guidance literature:

1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-one; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.666667h;

allyl bromide; In tetrahydrofuran; at 20 ℃; for 10h;

DOI:10.1016/j.tet.2006.01.021

Reference yield:

1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-ol (882512-68-7) → 1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one (882512-66-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 96 percent / PCC; silica gel / CH₂Cl₂ / 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.67 h / 20 °C

2.2: tetrahydrofuran; various solvent(s) / 10 h / 20 °C

2.3: 91 percent / tetrahydrofuran; various solvent(s) / 0.5 h / 180 °C

With silica gel; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2006.01.021

upstream raw materials:

1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-ol

1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-one

allyl bromide

1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-ol

Downstream raw materials:

3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol

3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-3-ol

2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetaldehyde

2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]ethanol