2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

Base Information

Chemical Name:2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide
CAS No.:177559-91-0
Molecular Formula:C₃₁H₂₆N₂O₃S
Molecular Weight:506.625
Hs Code.:

Synonyms:2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

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Chemical Property of 2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

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Technology Process of 2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

There total 10 articles about 2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.5%

: 79-37-8
oxalyl dichloride

: 1028264-80-3
8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizine

: 177559-91-0
2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

Guidance literature:: oxalyl dichloride; 8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizine; In tetrahydrofuran; at 0 ℃; for 0.5h;

With hydroxylamine; at 20 ℃; for 1h;

Reference yield:

: 1025963-82-9
(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-oxo-acetyl chloride

: 177559-91-0
2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jm960395q

Reference yield:

: 76509-17-6
3-benzyloxypyridine

: 177559-91-0
2-(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methylsulfanyl-indolizin-1-yl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: benzene / 2 h / 65 °C

2: 1.) aq. NaOH / 1.) EtOH, 30 min, 2.) ETOH, 1 h

3: 2.) 1,8-diazabicyclo<5.4.0>undec-7-ene, 3.) KOtBu

4: NaH / dimethylformamide / 2 h / Ambient temperature

5: aq. KOH / dimethylsulfoxide / 8 h / Heating

6: toluene / 1 h / Heating

7: benzene / 48 h / Ambient temperature

8: tetrahydrofuran / 1 h / 0 °C

9: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

With potassium hydroxide; ammonium hydroxide; sodium hydroxide; potassium tert-butylate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm960395q