N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine methyl ester

Base Information

Chemical Name:N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine methyl ester
CAS No.:198700-57-1
Molecular Formula:C₁₃H₁₄N₄O₃S₂
Molecular Weight:338.411
Hs Code.:

Synonyms:N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine methyl ester

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Chemical Property of N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine methyl ester

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Technology Process of N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine methyl ester

There total 3 articles about N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 40203-94-9
methyl (S)-2-isocyanato-3-phenylpropanoate

: 2349-67-9
5-amino-2,3-dihydro-1,3,4-thiadiazole-2-thione

: 198700-57-1
N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine methyl ester

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 17h;
DOI:10.1021/jm9803222

Reference yield:

: 75-44-5
phosgene

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 2349-67-9
2-Amino-5-mercapto-1,3,4-thiadiazole

: 198700-57-1
N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine methyl ester

Guidance literature:: With pyridine; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 198700-57-1
N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂; toluene / 2 h / 0 °C

2: 58 percent / tetrahydrofuran / 17 h / 0 - 20 °C

With pyridine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm9803222