N-(4'-chlorobenzoyl)deacetylthiocolchicine

Base Information

• Chemical Name: N-(4'-chlorobenzoyl)deacetylthiocolchicine
• CAS No.: 147950-73-0
• Molecular Formula: C₂₇H₂₆ClNO₅S
• Molecular Weight: 512.026
• Mol file: 147950-73-0.mol

Synonyms:N-(4'-chlorobenzoyl)deacetylthiocolchicine

Chemical Property of N-(4'-chlorobenzoyl)deacetylthiocolchicine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4'-chlorobenzoyl)deacetylthiocolchicine

There total 3 articles about N-(4'-chlorobenzoyl)deacetylthiocolchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

deacetylthiocolchicine (2731-16-0) + para-chlorobenzoic acid (74-11-3) → N-(4'-chlorobenzoyl)deacetylthiocolchicine (147950-73-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jm00062a021

Reference yield:

colchicine (64-86-8,54192-66-4) → N-(4'-chlorobenzoyl)deacetylthiocolchicine (147950-73-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂O / Ambient temperature

2: 2N aq. HCl / methanol / 90 °C

3: 92 percent / DCC / CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water;

DOI:10.1021/jm00062a021

Reference yield:

thiocolchicine (2730-71-4) → N-(4'-chlorobenzoyl)deacetylthiocolchicine (147950-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N aq. HCl / methanol / 90 °C

2: 92 percent / DCC / CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1021/jm00062a021

upstream raw materials:

deacetylthiocolchicine

para-chlorobenzoic acid

colchicine

thiocolchicine