[4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid

Base Information

Chemical Name:[4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid
CAS No.:1357621-26-1
Molecular Formula:C₂₉H₃₁N₅O₄S
Molecular Weight:545.662
Hs Code.:

Synonyms:[4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid

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Chemical Property of [4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid

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Technology Process of [4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid

There total 11 articles about [4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95882-33-0
3-cyclopentyl-3-oxopropanenitrile

: 1357621-26-1
[4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Reflux

2.1: sodium hydroxide / water; ethyl acetate / 2.5 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere

3.2: 60 °C / Inert atmosphere

4.1: lithium hydroxide / methanol; water / 20 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In methanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

: C₃₁H₃₅N₅O₄S

: 1357621-26-1
[4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid

Guidance literature:: C₃₁H₃₅N₅O₄S; With lithium hydroxide; In methanol; water; at 20 ℃;

With formic acid; In methanol; water;
DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

: 1357620-80-4
tert-butyl 4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-ylcarbamate

: 1357621-26-1
[4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere

2.2: 60 °C / Inert atmosphere

3.1: lithium hydroxide / methanol; water / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.11.019