ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

Base Information

• Chemical Name: ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate
• CAS No.: 1357621-14-7
• Molecular Formula: C₂₁H₂₄Cl₃N₃O₄
• Molecular Weight: 488.798
• Mol file: 1357621-14-7.mol

Synonyms:ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

Chemical Property of ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate

There total 5 articles about ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyclopentyl-3-oxopropanenitrile (95882-33-0) → ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate (1357621-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Reflux

2: sodium hydroxide / water; ethyl acetate / 2.5 h / 0 - 20 °C

With sodium hydroxide; In water; ethyl acetate;

DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate (897373-24-9) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate (1357621-14-7)

Guidance literature:

With sodium hydroxide; In water; ethyl acetate; at 0 - 20 ℃; for 2.5h;

DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

4-aminophenylacetic acid (1197-55-3) → ethyl [4-(3-cyclopentyl-5-{[(2,2,2-trichloroethoxy)carbonyl]amino}-1H-pyrazol-1-yl)phenyl]acetate (1357621-14-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: Reflux

3.1: sodium hydroxide / water; ethyl acetate / 2.5 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; sodium nitrite; In water; ethyl acetate;

DOI:10.1016/j.ejmech.2011.11.019

upstream raw materials:

ethyl 2-(4-(5-amino-3-cyclopentyl-1H-pyrazol-1-yl)phenyl)acetate

2,2,2-Trichloroethyl chloroformate

methyl cyclopentane carboxylate

4-aminophenylacetic acid

Downstream raw materials:

[4-(5-{[({4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}amino)carbonyl]amino}-3-cyclopentyl-1H-pyrazol-1-yl)phenyl]acetic acid