N-cyclopropyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenoxy)picolinamide

Base Information

• Chemical Name: N-cyclopropyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenoxy)picolinamide
• CAS No.: 1374123-68-8
• Molecular Formula: C₂₂H₁₈F₂N₄O₂S
• Molecular Weight: 440.473
• Mol file: 1374123-68-8.mol

Synonyms:N-cyclopropyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenoxy)picolinamide

Chemical Property of N-cyclopropyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenoxy)picolinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclopropyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenoxy)picolinamide

There total 5 articles about N-cyclopropyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenoxy)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.9%

4-(4-aminophenoxy)-N-cyclopropylpicolinamide (1374123-79-1) + 3,4-difluorophenyl isothiocyanate (113028-75-4) → N-cyclopropyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenoxy)picolinamide (1374123-68-8)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.03.018

Reference yield:

2-Picolinic acid (98-98-6) → N-cyclopropyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenoxy)picolinamide (1374123-68-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / 14 h / 45 - 72 °C

2.1: 2 h / 30 °C

3.1: tetrahydrofuran; methanol / 2 - 20 °C

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

4.2: 80 - 85 °C

5.1: dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

With thionyl chloride; potassium tert-butylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.03.018

Reference yield:

4-chloro-pyridine-2-carbonyl chloride (53750-66-6) → N-cyclopropyl-4-(4-(3-(3,4-difluorophenyl)thioureido)phenoxy)picolinamide (1374123-68-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 2 h / 30 °C

2.1: tetrahydrofuran; methanol / 2 - 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 80 - 85 °C

4.1: dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.03.018

upstream raw materials:

2-Picolinic acid

4-chloro-pyridine-2-carbonyl chloride

4-(4-aminophenoxy)-N-cyclopropylpicolinamide

3,4-difluorophenyl isothiocyanate