2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide

Base Information

Chemical Name:2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide
CAS No.:1308788-49-9
Molecular Formula:C₁₈H₁₉F₃N₂O
Molecular Weight:336.357
Hs Code.:

Synonyms:2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide

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Chemical Property of 2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide

Chemical Property:

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Technology Process of 2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide

There total 4 articles about 2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439896-97-5
2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanoic acid

: 1308788-49-9
2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / 85 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

With thionyl chloride; In dichloromethane;
DOI:10.1021/ja2001709

Reference yield:

: 939-99-1
4-trifluoromethylbenzyl chloride

: 1308788-49-9
2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 16 h / -78 - 20 °C

1.3: 0 °C

2.1: water; sodium hydroxide / methanol / 60 °C

2.2: pH 2

3.1: thionyl chloride / 3 h / 85 °C / Inert atmosphere

4.1: dichloromethane / 0 - 20 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; water; diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/ja2001709

Reference yield:

: 14248-25-0
2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester

: 1308788-49-9
2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / methanol / 60 °C

1.2: pH 2

2.1: thionyl chloride / 3 h / 85 °C / Inert atmosphere

3.1: dichloromethane / 0 - 20 °C / Inert atmosphere

With thionyl chloride; water; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ja2001709