3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione

Base Information

Chemical Name:3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione
CAS No.:1308788-91-1
Molecular Formula:C₁₉H₁₇F₃N₂O₂
Molecular Weight:362.351
Hs Code.:

Synonyms:3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione

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Technology Process of 3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione

There total 5 articles about 3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 201230-82-2
carbon monoxide

: 1308788-49-9
2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide

: 1308788-91-1
3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione

Guidance literature:: With dodecacarbonyl-triangulo-triruthenium; ethene; water; In toluene; at 160 ℃; for 120h; under 12920.9 Torr; regioselective reaction; Autoclave;
DOI:10.1021/ja2001709

Reference yield:

: C₁₂H₁₂ClF₃O

: 1308788-91-1
3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C / Inert atmosphere

2: dodecacarbonyl-triangulo-triruthenium; ethene; water / toluene / 120 h / 160 °C / 12920.9 Torr / Autoclave

With dodecacarbonyl-triangulo-triruthenium; ethene; water; In dichloromethane; toluene;
DOI:10.1021/ja2001709

Reference yield:

: 1439896-97-5
2,2-dimethyl-3-[4-(trifluoromethyl)phenyl]propanoic acid

: 1308788-91-1
3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / 85 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C / Inert atmosphere

3: dodecacarbonyl-triangulo-triruthenium; ethene; water / toluene / 120 h / 160 °C / 12920.9 Torr / Autoclave

With thionyl chloride; dodecacarbonyl-triangulo-triruthenium; ethene; water; In dichloromethane; toluene;
DOI:10.1021/ja2001709