2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester

Base Information

• Chemical Name: 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester
• CAS No.: 14248-25-0
• Molecular Formula: C₁₃H₁₅F₃O₂
• Molecular Weight: 260.256
• Mol file: 14248-25-0.mol

Synonyms:2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester

Chemical Property of 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester

There total 4 articles about 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) + 4-bromomethyltrifluoromethylbenzene (402-49-3) → 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester (14248-25-0)

Guidance literature:

Methyl isobutyrate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

4-bromomethyltrifluoromethylbenzene; In tetrahydrofuran; at -78 - 25 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201311105

Reference yield:

4-trifluoromethylbenzoic acid (455-24-3) → 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester (14248-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1: LiAlH₄ / diethyl ether

2: SOCl₂

With lithium aluminium tetrahydride; thionyl chloride; In diethyl ether;

DOI:10.1021/ja00976a022

Reference yield:

Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) + 4-trifluoromethylbenzyl chloride (939-99-1) → 2,2-Dimethyl-3-(p-trifluormethylphenyl)-propionsaeuremethylester (14248-25-0)

Guidance literature:

DOI:10.1021/ja00976a022

upstream raw materials:

Methyl isobutyrate

4-trifluoromethylbenzyl chloride

4-(trifluoromethyl)benzylic alcohol

4-trifluoromethylbenzoic acid

Downstream raw materials:

3-methyl-1-(8-quinolinyl)-3-(4-(trifluoromethyl)benzyl)-2-azetidinone

4-(4-(trifluoromethyl)phenyl)-3,3-dimethyl-1-(8-quinolinyl)-2-azetidinone

3-methyl-1-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)benzyl)pyrrolidine-2,5-dione

2,2-dimethyl-N-(pyridin-2-ylmethyl)-3-(4-(trifluoromethyl)phenyl)propanamide