Technology Process of 3-(4-((2,2-dimethylchroman-8-yl)methoxy)-3,5-difluorophenyl)-2-methylpropanoic acid
There total 9 articles about 3-(4-((2,2-dimethylchroman-8-yl)methoxy)-3,5-difluorophenyl)-2-methylpropanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C24H28F2O4;
With
lithium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 4h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: trifluoroacetic acid / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 50 °C
3: tetrahydrofuran / 2 h / Reflux
4: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C
5: di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h
6: lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C
With
di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; trifluoroacetic acid; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 50 °C
2: tetrahydrofuran / 2 h / Reflux
3: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C
4: di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h
5: lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C
With
di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
