4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine

Base Information

• Chemical Name: 4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine
• CAS No.: 1033442-55-5
• Molecular Formula: C₂₂H₂₇FN₂O₃
• Molecular Weight: 386.466
• Mol file: 1033442-55-5.mol

Synonyms:4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine

Chemical Property of 4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine

There total 1 articles about 4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(1R,1S)-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]-1-(2-fluoropyridin-4-yl)-methanol (1033442-47-5) + benzyl bromide (100-39-0) → 4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine (1033442-55-5)

Guidance literature:

(1R,1S)-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]-1-(2-fluoropyridin-4-yl)-methanol; With sodium hydride; In tetrahydrofuran; at 20 ℃;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/b718058f

Reference yield: 53.0%

glycolamide (598-42-5) + 4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine (1033442-55-5) → 2-{3-benzyl-4-[benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-pyridin-2-yloxy}-acetamide (1033442-60-2)

Guidance literature:

glycolamide; With potassium hydride; In dimethyl sulfoxide;

4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine; In dimethyl sulfoxide; at 55 ℃; for 120h;

DOI:10.1039/b718058f

Reference yield: 48.0%

glycolamide (598-42-5) + 4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine (1033442-55-5) → C24H31N3O5 (1033442-67-9) + 2-{4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-pyridin-2-yloxy}-acetamide (1033442-58-8)

Guidance literature:

glycolamide; With potassium hydride; In dimethyl sulfoxide;

4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-2-fluoro-pyridine; In dimethyl sulfoxide; at 55 ℃; for 2h;

DOI:10.1039/b718058f

upstream raw materials:

(1R,1S)-[(2S)-1-tert-butoxycarbonylpyrrolidin-2-yl]-1-(2-fluoropyridin-4-yl)-methanol

benzyl bromide

Downstream raw materials:

C₂₄H₃₁N₃O₅

2-{4-[(1R,1S)-benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-pyridin-2-yloxy}-acetamide

2-{3-benzyl-4-[benzyloxy-1-((2S)-1-tert-butoxycarbonyl-pyrrolidin-2-yl)-methyl]-pyridin-2-yloxy}-acetamide