2-BENZYLSULFANYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-5,7-DIOL

Base Information

• Chemical Name: 2-BENZYLSULFANYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-5,7-DIOL
• CAS No.: 98968-26-4
• Molecular Formula: C12H10 N4 O2 S
• Molecular Weight: 274.303
• Mol file: 98968-26-4.mol

Synonyms:2-benzylthio-5,7-dihydroxy-1,2,4-triazolo<1,5-a>pyrimidine

Chemical Property of 2-BENZYLSULFANYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-5,7-DIOL

Chemical Property:

• PSA: 108.58000
• LogP: 1.41550

Purity/Quality:

2-(BENZYLSULFANYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-5,7-DIOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYLSULFANYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-5,7-DIOL

There total 4 articles about 2-BENZYLSULFANYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-5,7-DIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-(benzylsulfanyl)-1H-[1,2,4]-triazol-3-amine (3922-47-2) + diethyl malonate (105-53-3) → 2-benzylthio-5,7-dihydroxy-1,2,4-triazolo<1,5-a>pyrimidine (98968-26-4)

Guidance literature:

5-(benzylsulfanyl)-1H-[1,2,4]-triazol-3-amine; diethyl malonate; With sodium methylate; In methanol; ethanol; for 120h; Reflux;

With hydrogenchloride; water;

DOI:10.1016/j.bmc.2009.03.018

Reference yield: 82.0%

3-(benzylthio)-1H-1,2,4-triazol-5-amine (3922-47-2) + malonic acid dimethyl ester (108-59-8) → 2-benzylthio-5,7-dihydroxy-1,2,4-triazolo<1,5-a>pyrimidine (98968-26-4)

Guidance literature:

With sodium methylate; In methanol; for 120h; Heating;

DOI:10.1002/jhet.5570360127

Reference yield:

5-(benzylsulfanyl)-1H-[1,2,4]-triazol-3-amine (3922-47-2) + malonic acid dimethyl ester (108-59-8) → 2-benzylthio-5,7-dihydroxy-1,2,4-triazolo<1,5-a>pyrimidine (98968-26-4)

Guidance literature:

With sodium methylate; In methanol; ethanol; water;

upstream raw materials:

malonic acid dimethyl ester

3-amino-5-benzylthio<1,2,4>triazole

3-(benzylthio)-1H-1,2,4-triazol-5-amine

5-(benzylsulfanyl)-1H-[1,2,4]-triazol-3-amine

Downstream raw materials:

2-benzylthio-5,7-dichloro-1,2,4-triazolo<1,5-a>pyrimidine

2-benzylthio-5-chloro-1,2,4-triazolo<1,5-a>pyrimidine

2-benzylthio-5-chloro-1,2,4-triazolo<1,5-a>pyrimidine

2-benzylthio-5-(2,2,2-trifluoroethoxy)-1,2,4-triazolo<1,5-a>pyrimidine