alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

Base Information

• Chemical Name: alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile
• CAS No.: 103523-45-1
• Molecular Formula: C₂₇H₃₈N₂O₅
• Molecular Weight: 470.609
• Mol file: 103523-45-1.mol

Synonyms:alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

Chemical Property of alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

There total 5 articles about alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]amino]ethyl]-3,4,5-trimethoxyphenylacetonitrile (103525-54-8) → alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile (103523-45-1)

Guidance literature:

With oxalic acid; In water; at 90 ℃; for 1h;

DOI:10.1248/cpb.36.367

Reference yield:

3-(2-methoxyphenoxy)propan-1-amine (3245-88-3) → alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile (103523-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) NaBH₄ / 1.) MeOH, 1 H, reflux, 2.) MeOH, ice water, 1 h, room temp.

2: 57 percent / oxalic acid / H₂O / 1 h / 90 °C

With sodium tetrahydroborate; oxalic acid; In water;

DOI:10.1248/cpb.36.367

Reference yield:

α-isopropyl-3,4,5-trimethoxybenzenacetonitrilie (36622-33-0) → alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile (103523-45-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 78.00 g / tetrahydrofuran / 4 h / Heating

2: 62.20 g / 10percent (COOH)2 / acetone; H₂O / 6 h / Heating

3: 2.) NaBH₄ / 1.) MeOH, 1 H, reflux, 2.) MeOH, ice water, 1 h, room temp.

4: 57 percent / oxalic acid / H₂O / 1 h / 90 °C

With sodium tetrahydroborate; oxalic acid; In tetrahydrofuran; water; acetone;

DOI:10.1248/cpb.36.367

upstream raw materials:

formaldehyd

alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]amino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

3-(2-methoxyphenoxy)propan-1-amine

α-isopropyl-3,4,5-trimethoxybenzenacetonitrilie