N-Methyl-N-(2-methylamino-ethyl)-benzamide

Base Information

• Chemical Name: N-Methyl-N-(2-methylamino-ethyl)-benzamide
• CAS No.: 98902-12-6
• Molecular Formula: C11H16 N2 O
• Molecular Weight: 192.261
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID60543367
• Nikkaji Number: J1.213.044I
• Wikidata: Q82420213
• Mol file: 98902-12-6.mol

Synonyms:N-Methyl-N-(2-methylamino-ethyl)-benzamide;98902-12-6;N-Methyl-N-[2-(methylamino)ethyl]benzamide;MFCD08689641;N-methyl-N-(2-(methylamino)ethyl)benzamide;N-METHYL-N-(2-METHYLAMINO-ETHYL)BENZAMIDE;SCHEMBL1833078;DTXSID60543367;AKOS013399284;CS-0368165

Chemical Property of N-Methyl-N-(2-methylamino-ethyl)-benzamide

Chemical Property:

• Vapor Pressure: 0.000184mmHg at 25°C
• Refractive Index: 1.528
• Boiling Point: 328.8°Cat760mmHg
• Flash Point: 152.7°C
• PSA: 32.34000
• Density: 1.03g/cm³
• LogP: 1.36890
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 192.126263138
• Heavy Atom Count: 14
• Complexity: 176

Purity/Quality:

99% ^*data from raw suppliers

N-Methyl-N-(2-methylamino-ethyl)-benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNCCN(C)C(=O)C1=CC=CC=C1

Technology Process of N-Methyl-N-(2-methylamino-ethyl)-benzamide

There total 7 articles about N-Methyl-N-(2-methylamino-ethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

N-Methyl-N-{2-[methyl-(toluene-4-sulfonyl)-amino]-ethyl}-benzamide → N-methyl-N-(2-methylamino-ethyl)-benzamide (98902-12-6)

Guidance literature:

With naphthalene; sodium; In 1,2-dimethoxyethane; at 25 ℃;

DOI:10.1021/jo981643o

Reference yield:

N-[2-(Benzyl-methyl-amino)-ethyl]-N-methyl-benzamide (98902-01-3) → N-methyl-N-(2-methylamino-ethyl)-benzamide (98902-12-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; ethanol; at 80 ℃; under 51714.8 Torr; Yield given;

DOI:10.1021/jm00151a003

Reference yield:

benzoyl chloride (98-88-4) + N,N`-dimethylethylenediamine (110-70-3) → N,N′-(ethane-1,2-diyl)bis(N-methylbenzamide) (24768-61-4) + N-methyl-N-(2-methylamino-ethyl)-benzamide (98902-12-6)

Guidance literature:

N,N`-dimethylethylenediamine; With n-butyllithium; In tetrahydrofuran; at 20 ℃;

benzoyl chloride; In tetrahydrofuran;

DOI:10.1021/jo9908501

upstream raw materials:

N-[2-(Benzyl-methyl-amino)-ethyl]-N-methyl-benzamide

benzoyl chloride

N,N`-dimethylethylenediamine

1-benzoylimidazole

Downstream raw materials:

C₂₁H₂₀FN₃O₃

acetophenone

N-{2-[(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-methyl-amino]-ethyl}-N-methyl-benzamide

Refernces

• 1、 Zhang, Zhongxing,Yin, Zhiwei,Meanwell, Nicholas A.,Kadow, John F.,Wang, Tao. "Selective Monoacylation of Symmetrical Diamines via Prior Complexation with Boron". . p. 3399 - 3402. Retrieved 2007/10/03.
• 2、 Chung, Eun-Ae,Cho, Chang-Woo,Ahn, Kyo Han. "Direct conversion of carboxylic esters into ketones using organoaluminum complexes". . p. 7590 - 7591. Retrieved 2007/10/03.