Carbamic acid, [2-(1H-imidazol-4-yl)ethyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [2-(1H-imidazol-4-yl)ethyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 98870-64-5
• Molecular Formula: C10H17 N3 O2
• Molecular Weight: 211.264
• Hs Code.: 2933290090
• Mol file: 98870-64-5.mol

Synonyms:Carbamicacid, [2-(1H-imidazol-4-yl)ethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, [2-(1H-imidazol-4-yl)ethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 70.50000
• LogP: 1.68130

Purity/Quality:

98%min ^*data from raw suppliers

N-[2-(1H-imidazol-5-yl)ethyl]-Carbamicacid1,1-dimethylethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [2-(1H-imidazol-4-yl)ethyl]-, 1,1-dimethylethyl ester (9CI)

There total 6 articles about Carbamic acid, [2-(1H-imidazol-4-yl)ethyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + histamine dichloride (56-92-8) → Nα-(tert-butoxycarbonyl)histamine (98870-64-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2018.02.004

Reference yield: 94.0%

N,1-bis(t-butoxycarbonyl)histamine (127119-12-4) → Nα-(tert-butoxycarbonyl)histamine (98870-64-5)

Guidance literature:

With silica gel; In dichloromethane; at 50 ℃; for 10h; under 0.2 Torr;

DOI:10.1016/0040-4039(95)02398-4

Reference yield: 94.0%

Nα,Nτ-bis(tert-butoxycarbonyl)histamine → tert-butyl 2-(1H-imidazol-5-yl)ethylcarbamate (98870-64-5)

Guidance literature:

With water; at 100 ℃; for 0.166667h;

DOI:10.1039/b910239f

upstream raw materials:

N,1-bis(t-butoxycarbonyl)histamine

di-tert-butyl dicarbonate

histamine dichloride

histamine dihydrochloride

Downstream raw materials:

2-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-ethylamine

osmium dibipyridyl t-Boc histamine

4-[2-(tert-butoxycarbonylamino)ethyl]-1,3-dibenzyl-1H-imidazol-3-ium bromide

tert-butyl 2-(1-benzyl-1H-imidazol-4-yl)ethylcarbamate