N-(2-HYDROXYBENZOYL)PYRROLIDINE 97

Base Information

• Chemical Name: N-(2-HYDROXYBENZOYL)PYRROLIDINE 97
• CAS No.: 98841-68-0
• Molecular Formula: C11H13 N O2
• Molecular Weight: 191.23
• Mol file: 98841-68-0.mol

Synonyms:Pyrrolidine,1-(2-hydroxybenzoyl)- (9CI); N-(2-Hydroxybenzoyl)pyrrolidine; NSC 14611

Chemical Property of N-(2-HYDROXYBENZOYL)PYRROLIDINE 97

Chemical Property:

• Vapor Pressure: 1.13E-05mmHg at 25°C
• Melting Point: 118-124 °C(lit.)
• Refractive Index: 1.606
• Boiling Point: 359.7°Cat760mmHg
• Flash Point: 171.4°C
• PSA: 40.54000
• Density: 1.231g/cm³
• LogP: 1.56610

Purity/Quality:

97% ^*data from raw suppliers

N-(2-Hydroxybenzoyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-HYDROXYBENZOYL)PYRROLIDINE 97

There total 10 articles about N-(2-HYDROXYBENZOYL)PYRROLIDINE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

pyrrolidine (123-75-1) + 2-(trifluoromethyl)phenol (444-30-4) → (2-hydroxy-phenyl)(pyrrolidin-1-yl)methanone (98841-68-0)

Guidance literature:

With water; sodium hydroxide; In 1,4-dioxane; at 75 ℃; for 18.5h;

DOI:10.1021/ol100507n

Reference yield: 94.0%

n-benzoylpyrrolidine (3389-54-6) → (2-hydroxy-phenyl)(pyrrolidin-1-yl)methanone (98841-68-0)

Guidance literature:

With [bis(acetoxy)iodo]benzene; [Ru(MesCO₂)₂(p-cymene)]; trifluoroacetic acid; trifluoroacetic anhydride; at 120 ℃; for 30h;

DOI:10.1021/ol3018819

Reference yield: 92.3%

pyrrolidine hydrochloride (25150-61-2) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → (2-hydroxy-phenyl)(pyrrolidin-1-yl)methanone (98841-68-0)

Guidance literature:

salicylic acid; With dicyclohexyl-carbodiimide; at 50 ℃; for 0.5h; Milling;

pyrrolidine hydrochloride; With sodium hydrogencarbonate; for 0.75h; Milling;

upstream raw materials:

pyrrolidine

phenyl Salicylate

methyl salicylate

phosphorous acid trimethyl ester

Downstream raw materials:

[2-(1-biphenyl-4-yl-allyloxy)-phenyl]-pyrrolidin-1-yl-methanone

4-hydroxy-5-(pyrrolidine-1-carbonyl)benzene-1,3-disulfonyl dichloride

2-((pyrrolidin-1-yl)methyl)phenol