2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

• Chemical Name: 2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
• CAS No.: 1201645-42-2
• Molecular Formula: C₃₂H₂₃N₅
• Molecular Weight: 477.568
• Mol file: 1201645-42-2.mol

Synonyms:2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Chemical Property of 2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

There total 22 articles about 2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

2-bromo-9H-carbazole (3652-90-2) + 2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (1201644-97-4) → 2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (1201645-42-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 155 ℃; for 0.5h; Microwave irradiation;

Reference yield:

2-methyl-2-(4-methylphenyl)propionitrile (40119-34-4) → 2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (1201645-42-2)

Guidance literature:

Multi-step reaction with 13 steps

1.1: pyridine; potassium permanganate / water / 1 h / Reflux

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

3.2: 25 °C

4.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

5.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

6.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

7.1: hydrogenchloride / acetone / 24 h

8.1: hydrogenchloride / water / 24 h

9.1: potassium acetate / ethanol / 5 h / Reflux

10.1: hydrogenchloride; titanium(III) chloride

11.1: potassium acetate / toluene

12.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 110 °C / Inert atmosphere

13.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.5 h / 155 °C / Microwave irradiation

With pyridine; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium permanganate; titanium(III) chloride; oxalyl dichloride; potassium acetate; sodium carbonate; caesium carbonate; ozone; N,N-dimethyl-formamide; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

4-(1-cyano-1-methylethyl)benzoic acid chloride → 2-(4-(8-(9H-carbazol-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (1201645-42-2)

Guidance literature:

Multi-step reaction with 11 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

1.2: 25 °C

2.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

3.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

4.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

5.1: hydrogenchloride / acetone / 24 h

6.1: hydrogenchloride / water / 24 h

7.1: potassium acetate / ethanol / 5 h / Reflux

8.1: hydrogenchloride; titanium(III) chloride

9.1: potassium acetate / toluene

10.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 110 °C / Inert atmosphere

11.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.5 h / 155 °C / Microwave irradiation

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; titanium(III) chloride; potassium acetate; sodium carbonate; caesium carbonate; ozone; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

upstream raw materials:

2-bromo-9H-carbazole

2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

4-(1-cyano-1-methylethyl)benzoic acid

6-bromo-4-chloro-3-nitroquinoline