2-BROMOCARBAZOLE

Base Information

• Chemical Name: 2-BROMOCARBAZOLE
• CAS No.: 3652-90-2
• Molecular Formula: C12H8BrN
• Molecular Weight: 246.106
• Hs Code.: 2933990090
• Mol file: 3652-90-2.mol

Synonyms:9H-Carbazole, 2-bromo-;2-Bromocarbazole;

Chemical Property of 2-BROMOCARBAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 253.0 to 257.0 °C
• Refractive Index: 1.784
• Boiling Point: 409.228 °C at 760 mmHg
• PKA: 16.17±0.30(Predicted)
• Flash Point: 201.294 °C
• PSA: 15.79000
• Density: 1.617 g/cm³
• LogP: 4.08360
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-9H-carbazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sensitive fluorogenic substrate for urokinase.

Technology Process of 2-BROMOCARBAZOLE

There total 29 articles about 2-BROMOCARBAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-9-(pyrimidin-2-yl)-9H-carbazole → 2-bromo-9H-carbazole (3652-90-2)

Guidance literature:

With N¹-(4-hydroxy-2,6-dimethylphenyl)-N²-(4-hydroxy-3,5-dimethylphenyl)oxalamide; water; copper(l) chloride; sodium t-butanolate; In dimethyl sulfoxide; at 110 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.7b01568

Reference yield: 89.0%

4'-bromo-2-nitrobiphenyl (35450-34-1) → 2-bromo-9H-carbazole (3652-90-2)

Guidance literature:

With triphenylphosphine; In 1,2-dichloro-benzene; at 170 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acschemneuro.8b00291

Reference yield: 83.0%

9H-carbazol-2-yl trifluoromethanesulfonate (870703-52-9) → 2-bromo-9H-carbazole (3652-90-2)

Guidance literature:

With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; t-BuBrettPhos; potassium bromide; In 1,4-dioxane; at 130 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol202098h

upstream raw materials:

7-bromo-2,3,4,9-tetrahydro-1H-carbazole

4-Brom-2-azidobiphenyl

4'-bromo-2-nitrobiphenyl

1,4-dibromo-2-nitrobenzene

Downstream raw materials:

3-(5,10,15-tris(4-methylphenyl)porphyrinato(zinc)(II)-20-yl)-9-hexyl-carbazole

3-(5,10,15-tris(4-methylphenyl)porphyrinato(palladium)(II)-20-yl)-9-hexyl-carbazole

bis(3,3'-{5',15'-diphenylporphyrinato(zinc(II))-10',20'-yl})-9-hexyl-carbazole

9-hexylcarbazol-6-[4',4',5',5'-tetramethyl(1',3',2')dioxaborolan-2-yl]

Refernces

• 1、 -. "Preparation of 2 - substituted oxazole compounds". Paragraph 0033; 0034. . Retrieved 2018/02/28.
• 2、 -. "Tetradentate platinum and palladium complex emitters containing phenyl-pyrazole and its analogues". Paragraph 681; 684. . Retrieved 2018/07/29.