2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
CAS No.:1201644-97-4
Molecular Formula:C₂₈H₂₉BN₄O₃
Molecular Weight:480.374
Hs Code.:

Synonyms:2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

There total 20 articles about 2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1201643-72-2
2-(4-(3-acetyl-8-bromo-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

: 73183-34-3
bis(pinacol)diborane

: 1201644-97-4
2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 110 ℃; for 2h; Inert atmosphere;

Reference yield:

: 40119-34-4
2-methyl-2-(4-methylphenyl)propionitrile

: 1201644-97-4
2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 12 steps

1.1: pyridine; potassium permanganate / water / 1 h / Reflux

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

3.2: 25 °C

4.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

5.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

6.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

7.1: hydrogenchloride / acetone / 24 h

8.1: hydrogenchloride / water / 24 h

9.1: potassium acetate / ethanol / 5 h / Reflux

10.1: hydrogenchloride; titanium(III) chloride

11.1: potassium acetate / toluene

12.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 110 °C / Inert atmosphere

With pyridine; hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; potassium permanganate; titanium(III) chloride; oxalyl dichloride; potassium acetate; caesium carbonate; ozone; N,N-dimethyl-formamide; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1201644-97-4
2-(4-(3-acetyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: aluminum (III) chloride / dichloromethane / 0.17 h / 25 °C

2.2: 25 °C

3.1: sodium tetrahydroborate; trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

4.1: caesium carbonate / tetrahydrofuran; methanol / 2 h / 70 °C

5.1: ozone / N,N-dimethyl-formamide / 0.13 h / -5 °C

6.1: hydrogenchloride / acetone / 24 h

7.1: hydrogenchloride / water / 24 h

8.1: potassium acetate / ethanol / 5 h / Reflux

9.1: hydrogenchloride; titanium(III) chloride

10.1: potassium acetate / toluene

11.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 2 h / 110 °C / Inert atmosphere

With hydrogenchloride; aluminum (III) chloride; sodium tetrahydroborate; titanium(III) chloride; potassium acetate; sodium hydride; caesium carbonate; ozone; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;