N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane triethyl ester

Base Information

• Chemical Name: N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane triethyl ester
• CAS No.: 220886-01-1
• Molecular Formula: C₂₉H₄₄N₂O₁₂
• Molecular Weight: 612.675

Synonyms:N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane triethyl ester

Chemical Property of N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane triethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane triethyl ester

There total 2 articles about N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane triethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-[2-Amino-3-(2-ethoxycarbonyl-ethoxy)-2-(2-ethoxycarbonyl-ethoxymethyl)-propoxy]-propionic acid ethyl ester (132491-90-8) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane triethyl ester (220886-01-1)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetonitrile;

DOI:10.1021/jm981078h

Reference yield:

tris(cyanoethoxymethyl)aminomethane (132491-89-5) → N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane triethyl ester (220886-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄

2: 84 percent / NMM; IBCF / tetrahydrofuran / 24 h / 20 °C

With 4-methyl-morpholine; sulfuric acid; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1021/jo0257795

Reference yield: 85.0%

N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane triethyl ester (220886-01-1) → N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane (220886-02-2)

Guidance literature:

With sodium hydroxide; In methanol; water;

DOI:10.1021/jo0257795

upstream raw materials:

3-[2-Amino-3-(2-ethoxycarbonyl-ethoxy)-2-(2-ethoxycarbonyl-ethoxymethyl)-propoxy]-propionic acid ethyl ester

N-(Benzyloxycarbonyl)glycine

tris(cyanoethoxymethyl)aminomethane

Downstream raw materials:

N-(N-benzyloxycarbonyl-glycinyl)-tris(carboxyethoxymethyl)aminomethane

({2-[2-(3-amino-propylcarbamoyl)-ethoxy]-1,1-bis-[2-(3-amino-propylcarbamoyl)-ethoxymethyl]-ethylcarbamoyl}-methyl)-carbamic acid benzyl ester

[3-(3-{2-(2-benzyloxycarbonylamino-acetylamino)-3-[2-(3-tert-butoxycarbonylamino-propylcarbamoyl)-ethoxy]-2-[2-(3-tert-butoxycarbonylamino-propylcarbamoyl)-ethoxymethyl]-propoxy}-propionylamino)-propyl]-carbamic acid tert-butyl ester

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