5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide
CAS No.:1219737-04-8
Molecular Formula:C₂₂H₂₁Cl₃N₄O₂S
Molecular Weight:511.859
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide

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Chemical Property of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide

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Technology Process of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide

There total 6 articles about 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1219737-03-7
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazole-3-carbohydrazide

: 75-98-9
Trimethylacetic acid

: 1219737-04-8
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield: 63.0%

: 1219737-03-7
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazole-3-carbohydrazide

: 815-17-8
trimethylpyruvic acid

: 1219737-04-8
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide

Guidance literature:: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazole-3-carbohydrazide; trimethylpyruvic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 24437-53-4
1-(4-chlorophenyl)-2-methylthio ethanone

: 1219737-04-8
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-N'-pivaloyl-1H-pyrazole-3-carbohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tert-butyl methyl ether / 1.5 h / -40 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: ethanol / 17 h / 20 °C / Reflux

3.1: hydrazine hydrate / ethanol / 2 h / 90 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; In ethanol; dichloromethane; tert-butyl methyl ether;