4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol

Base Information

Chemical Name:4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol
CAS No.:262589-71-9
Molecular Formula:C₂₂H₁₈FN₃OS₂
Molecular Weight:423.535
Hs Code.:

4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1<i>H</i>-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol

Synonyms:4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol

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Chemical Property of 4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol

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Technology Process of 4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol

There total 3 articles about 4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 72882-75-8
4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3-dihydro-imidazole-2-thione

: 262589-83-3
4-hydroxymethyl-2-methylsulfanylphenol

: 262589-71-9
4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol

Guidance literature:: With acetic acid; at 20 ℃; for 2h;
DOI:10.1021/jm020873z

Reference yield:

: 87346-53-0
4-methoxy-3-methylsulphenylbenzoic acid

: 262589-71-9
4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / HBr; AcOH / 6 h / Heating

2: 57 percent / LiAlH₄ / tetrahydrofuran / 17 h / 60 °C

3: 47 percent / 10percent HCl; AcOH / 2 h / 20 °C

With lithium aluminium tetrahydride; hydrogen bromide; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm020873z

Reference yield:

: 262589-81-1
4-hydroxy-3-methylsulfanylbenzoic acid

: 262589-71-9
4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / LiAlH₄ / tetrahydrofuran / 17 h / 60 °C

2: 47 percent / 10percent HCl; AcOH / 2 h / 20 °C

With lithium aluminium tetrahydride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm020873z