4-amino-3-(3-{2-[bis-(2-{tert-butoxycarbonylamino}ethyl)amino]ethyl}thioureido)benzoic acid methyl ester

Base Information

• Chemical Name: 4-amino-3-(3-{2-[bis-(2-{tert-butoxycarbonylamino}ethyl)amino]ethyl}thioureido)benzoic acid methyl ester
• CAS No.: 848408-62-8
• Molecular Formula: C₂₅H₄₂N₆O₆S
• Molecular Weight: 554.711
• Mol file: 848408-62-8.mol

Synonyms:4-amino-3-(3-{2-[bis-(2-{tert-butoxycarbonylamino}ethyl)amino]ethyl}thioureido)benzoic acid methyl ester

Chemical Property of 4-amino-3-(3-{2-[bis-(2-{tert-butoxycarbonylamino}ethyl)amino]ethyl}thioureido)benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-3-(3-{2-[bis-(2-{tert-butoxycarbonylamino}ethyl)amino]ethyl}thioureido)benzoic acid methyl ester

There total 3 articles about 4-amino-3-(3-{2-[bis-(2-{tert-butoxycarbonylamino}ethyl)amino]ethyl}thioureido)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Methyl 3,4-diaminobenzoate (36692-49-6) + 1,1'-Thiocarbonyldiimidazole (6160-65-2) + {2-[(2-amino-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester (161038-11-5) → 4-amino-3-(3-{2-[bis-(2-{tert-butoxycarbonylamino}ethyl)amino]ethyl}thioureido)benzoic acid methyl ester (848408-62-8)

Guidance literature:

1,1'-Thiocarbonyldiimidazole; {2-[(2-amino-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester; With 1H-imidazole; In acetonitrile; at 20 ℃; for 1h;

Methyl 3,4-diaminobenzoate; In acetonitrile; at 20 - 50 ℃;

DOI:10.1021/ja0443934

Reference yield:

2,2',2''-triaminotriethylamine (4097-89-6) → 4-amino-3-(3-{2-[bis-(2-{tert-butoxycarbonylamino}ethyl)amino]ethyl}thioureido)benzoic acid methyl ester (848408-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 53 percent / tetrahydrofuran / 0 - 20 °C

2.1: imidazole / acetonitrile / 1 h / 20 °C

2.2: 88 percent / acetonitrile / 20 - 50 °C

With 1H-imidazole; In tetrahydrofuran; acetonitrile;

DOI:10.1021/ja0443934

Reference yield:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) → 4-amino-3-(3-{2-[bis-(2-{tert-butoxycarbonylamino}ethyl)amino]ethyl}thioureido)benzoic acid methyl ester (848408-62-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 48.5 h / 0 - 20 °C

2.1: 1H-imidazole / acetonitrile / 1 h / 0 - 20 °C

2.2: 20 - 50 °C

With 1H-imidazole; In tetrahydrofuran; acetonitrile;

DOI:10.3762/bjoc.11.55

upstream raw materials:

Methyl 3,4-diaminobenzoate

1,1'-Thiocarbonyldiimidazole

{2-[(2-amino-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester

2,2',2''-triaminotriethylamine

Downstream raw materials:

2-[2-(bis-{2-[3-(2-nitrophenyl)thioureido]ethyl}amino)ethylamino]-3H-benzimidazole-5-carboxylic acid methyl ester

2-[2-(bis-{2-[3-(2-aminophenyl)thioureido]ethyl}amino)ethylamino]-3H-benzimidazole-5-carboxylic acid methyl ester