methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate

Base Information

Chemical Name:methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate
CAS No.:213881-59-5
Molecular Formula:C₁₈H₁₄F₃NO₅S
Molecular Weight:413.374
Hs Code.:

Synonyms:methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate

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Chemical Property of methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate

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Technology Process of methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate

There total 4 articles about methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 213881-58-4
methyl 1-benzyl-3-hydroxy-1H-2-indolecarboxylate

: 213881-59-5
methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(98)00649-8

Reference yield:

: 31827-04-0
methyl 3-hydroxy-1H-indole-2-carboxylate

: 213881-59-5
methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / imidazole / tetrahydrofuran / 24 h / Heating

2: 65 percent / NaH / tetrahydrofuran / 16 h / 20 °C

3: 60 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: 97 percent / NaH / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; 1: Substitution / 2: Substitution / 3: Hydrolysis / 4: Substitution;
DOI:10.1016/S0040-4020(98)00649-8

Reference yield:

: 213881-57-3
methyl 3-(tert-butyldimethylsilyloxy)-1H-2-indolecarboxylate

: 213881-59-5
methyl 1-benzyl-3-[(trifluoromethyl)sulfonyloxy]-1H-2-indolecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / NaH / tetrahydrofuran / 16 h / 20 °C

2: 60 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: 97 percent / NaH / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; 1: Substitution / 2: Hydrolysis / 3: Substitution;
DOI:10.1016/S0040-4020(98)00649-8