Methyl 3-hydroxy-1H-indole-2-carboxylate

Base Information

Chemical Name:Methyl 3-hydroxy-1H-indole-2-carboxylate
CAS No.:31827-04-0
Molecular Formula:C10H9 N O3
Molecular Weight:191.186
Hs Code.:2933990090
DSSTox Substance ID:DTXSID10392549
Nikkaji Number:J996.977B
Wikidata:Q72491321
Mol file:31827-04-0.mol

Synonyms:31827-04-0;3-Hydroxyindole-2-carboxylic acid methyl ester;Methyl 3-hydroxy-1H-indole-2-carboxylate;METHYL 3-HYDROXYINDOLE-2-CARBOXYLATE;3-HYDROXY-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER;3-HO-ICA-OME;2-[hydroxy(methoxy)methylidene]-1H-indol-3-one;SCHEMBL4207606;DTXSID10392549;GHRXPKBLHFSXTB-UHFFFAOYSA-N;MFCD00030205;AKOS002664613;AB01492;BP-11111;BS-28038;BB 0257330;CS-0150860;FT-0639000;EN300-49725;F53546;H-6358;2-[methoxy(oxidanyl)methylidene]-1H-indol-3-one;A821012

Suppliers and Price of Methyl 3-hydroxy-1H-indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl3-Hydroxyindole-2-carboxylate
2.5g
$ 970.00

SynQuest Laboratories
Methyl 3-hydroxyindole-2-carboxylate
250 mg
$ 244.00

Medical Isotopes, Inc.
Methyl3-Hydroxyindole-2-carboxylate
250 mg
$ 860.00

J&W Pharmlab
3-Hydroxy-1H-indole-2-carboxylicacidmethylester 96%
5g
$ 598.00

J&W Pharmlab
3-Hydroxy-1H-indole-2-carboxylicacidmethylester 96%
1g
$ 198.00

Crysdot
Methyl3-hydroxy-1H-indole-2-carboxylate 95+%
10g
$ 355.00

Crysdot
Methyl3-hydroxy-1H-indole-2-carboxylate 95+%
25g
$ 640.00

Chemenu
3-Hydroxyindole-2-carboxylicacidmethylester 95%
25g
$ 604.00

Chemenu
3-Hydroxyindole-2-carboxylicacidmethylester 95%
10g
$ 335.00

BroadPharm
METHYL3-HYDROXYINDOLE-2-CARBOXYLATE
250 MG
$ 105.00

Total 22 raw suppliers

Chemical Property of Methyl 3-hydroxy-1H-indole-2-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:360.516°C at 760 mmHg
Flash Point:171.834°C
PSA：62.32000
Density:1.383
LogP:1.66010
Storage Temp.:2-8°C
Solubility.:Methanol
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:191.058243149
Heavy Atom Count:14
Complexity:231

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-Hydroxyindole-2-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C(C2=CC=CC=C2N1)O
Uses Methyl 3-Hydroxyindole-2-carboxylate (cas# 31827-04-0) is a compound useful in organic synthesis.

Technology Process of Methyl 3-hydroxy-1H-indole-2-carboxylate

There total 16 articles about Methyl 3-hydroxy-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 13622-59-8
N-(2-methoxycarbonylphenyl)glycine methyl ester

: 31827-04-0
methyl 3-hydroxy-1H-indole-2-carboxylate

Guidance literature:: With sodium methylate; In methanol; toluene; Reflux;
DOI:10.2174/1570178615666180212152030

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 31827-04-0
methyl 3-hydroxy-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C

2: potassium tert-butylate / tetrahydrofuran / 0 °C

With potassium tert-butylate; sodium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Dieckmann condensation;
DOI:10.3987/COM-10-S(E)127