5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one

Base Information

Chemical Name:5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one
CAS No.:607739-49-1
Molecular Formula:C₂₅H₂₀F₆N₂O₂
Molecular Weight:494.436
Hs Code.:

Synonyms:5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one

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Chemical Property of 5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one

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Technology Process of 5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one

There total 5 articles about 5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 16419-60-6
2-Methylphenylboronic acid

: 607739-45-7
5-[3,5-bis(trifluoromethyl)benzyl]-7-chloro-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one

: 607739-49-1
5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; toluene; Heating;
DOI:10.1016/j.bmc.2005.06.015

Reference yield:

: 78607-36-0
2-chloro-3-iodopyridine

: 607739-49-1
5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropylamide / tetrahydrofuran / -78 °C

1.2: 81 percent / tetrahydrofuran

2.1: thionyl chloride / dimethylformamide / 2 h / Heating

3.1: 92 percent / triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

4.1: 71 percent / K₂CO₃ / ethanol / 6 h / Heating

5.1: 98 percent / Na₂CO₃ / Pd(PPh₃)4 / toluene; dioxane / Heating

With thionyl chloride; sodium carbonate; potassium carbonate; triethylamine; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene; 5.1: Suzuki coupling;
DOI:10.1016/j.bmc.2005.06.015

Reference yield:

: 544671-78-5
2-chloro-4-iodo-3-pyridinecarboxylic acid

: 607739-49-1
5-[3,5-bis(trifluoromethyl)benzyl]-7-(2-methylphenyl)-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]-1,5-oxazocin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / dimethylformamide / 2 h / Heating

2: 92 percent / triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

3: 71 percent / K₂CO₃ / ethanol / 6 h / Heating

4: 98 percent / Na₂CO₃ / Pd(PPh₃)4 / toluene; dioxane / Heating

With thionyl chloride; sodium carbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene; 4: Suzuki coupling;
DOI:10.1016/j.bmc.2005.06.015