4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)nicotinonitrile

Base Information

Chemical Name:4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)nicotinonitrile
CAS No.:1436405-41-2
Molecular Formula:C₂₉H₂₈ClN₅O₄S
Molecular Weight:578.091
Hs Code.:

Synonyms:4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)nicotinonitrile

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Chemical Property of 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)nicotinonitrile

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Technology Process of 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)nicotinonitrile

There total 11 articles about 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 845658-68-6
N-((5-bromofuran-2-yl)methyl)-2-(methylsulfonyl)ethanamine

: 1436405-39-8
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile

: 1436405-41-2
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)nicotinonitrile

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium acetate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 1436405-41-2
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 2 h / 20 °C

1.2: 4 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium acetate / 1-methyl-pyrrolidin-2-one / 3 h / 110 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium acetate; In 1-methyl-pyrrolidin-2-one; methanol; 2.1: |Heck Reaction;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 1436405-41-2
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 60 °C

2.1: hydrogenchloride; iron / water; ethanol / 1 h / 70 °C

3.1: methanesulfonic acid / ethanol / 2 h / 70 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 4 h / 110 °C / Inert atmosphere

5.1: bis-triphenylphosphine-palladium(II) chloride; sodium acetate / 1-methyl-pyrrolidin-2-one / 3 h / 110 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; methanesulfonic acid; sodium acetate; iron; potassium carbonate; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide; toluene; 4.1: |Stille Cross Coupling / 5.1: |Heck Reaction;
DOI:10.1016/j.bmc.2013.03.053