4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile

Base Information

Chemical Name:4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile
CAS No.:1436405-39-8
Molecular Formula:C₂₁H₁₇ClN₄O
Molecular Weight:376.845
Hs Code.:

Synonyms:4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile

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Chemical Property of 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile

Chemical Property:

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Technology Process of 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile

There total 9 articles about 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1436405-38-7
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-5-iodo-6-methylnicotinonitrile

: 7486-35-3
tri-n-butyl(vinyl)tin

: 1436405-39-8
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In toluene; at 110 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 1436405-39-8
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 12 h / 60 °C

2.1: hydrogenchloride; iron / water; ethanol / 1 h / 70 °C

3.1: methanesulfonic acid / ethanol / 2 h / 70 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 4 h / 110 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; methanesulfonic acid; iron; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene; 4.1: |Stille Cross Coupling;
DOI:10.1016/j.bmc.2013.03.053

Reference yield:

: 67367-33-3
4-hydroxy-6-methylnicotinic acid

: 1436405-39-8
4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-6-methyl-5-vinylnicotinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / methanol / 5 h / Reflux

1.2: 20 °C

2.1: Iodine monochloride; acetic acid / 20 °C

3.1: trichlorophosphate / diethylene glycol dimethyl ether / 2 h / 90 °C

4.1: methanesulfonic acid / ethanol / 2 h / 70 °C

5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / toluene / 4 h / 110 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; methanesulfonic acid; Iodine monochloride; acetic acid; trichlorophosphate; In methanol; ethanol; diethylene glycol dimethyl ether; toluene; 5.1: |Stille Cross Coupling;
DOI:10.1016/j.bmc.2013.03.053