{2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

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Chemical Name:{2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid
CAS No.:1415043-78-5
Molecular Formula:C₂₄H₂₂N₂O₅S
Molecular Weight:450.515
Hs Code.:

Synonyms:{2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

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Chemical Property of {2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

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Technology Process of {2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

There total 13 articles about {2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1415043-77-4
Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

: 1415043-78-5
{2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

Guidance literature:: Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium hydroxide; In water;

With hydrogenchloride; In water; pH=4 - 5;

Reference yield:

: 14432-12-3
4-Amino-2-chloropyridine

: 1415043-78-5
{2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 55 °C

2.1: tetrahydrofuran / 1 h / Cooling with ice

3.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice

4.1: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

5.1: acetic anhydride; hydrogen iodide / water / Cooling with ice

5.2: 168 h

6.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.17 h / 20 °C / Cooling with ice; Inert atmosphere

6.2: 5 h / 20 °C

7.1: water; acetic acid / 96 h / 130 °C

7.3: pH 2 - 3

8.1: sulfuric acid / 75 °C

9.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / Inert atmosphere; Cooling with ice

10.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

10.3: pH 4 - 5

With N-iodo-succinimide; copper(l) iodide; lithium hydroxide monohydrate; sulfuric acid; water; hydrogen iodide; acetic anhydride; sodium hydride; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; oil;

Reference yield:

: 234108-74-8
(2-chloro-3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester

: 1415043-78-5
{2,5-Dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice

2.1: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

3.1: acetic anhydride; hydrogen iodide / water / Cooling with ice

3.2: 168 h

4.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.17 h / 20 °C / Cooling with ice; Inert atmosphere

4.2: 5 h / 20 °C

5.1: water; acetic acid / 96 h / 130 °C

5.3: pH 2 - 3

6.1: sulfuric acid / 75 °C

7.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / Inert atmosphere; Cooling with ice

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 20 °C

8.3: pH 4 - 5

With copper(l) iodide; lithium hydroxide monohydrate; sulfuric acid; water; hydrogen iodide; acetic anhydride; sodium hydride; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; oil;