Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

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Chemical Name:Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate
CAS No.:1415043-77-4
Molecular Formula:C₂₆H₂₆N₂O₅S
Molecular Weight:478.569
Hs Code.:

Synonyms:Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

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Chemical Property of Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

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Technology Process of Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

There total 12 articles about Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415043-76-3
Ethyl {2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

: 74-88-4
methyl iodide

: 1415043-77-4
Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

Guidance literature:: Ethyl {2-methyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate; With sodium hydride; In N,N-dimethyl-formamide; oil; for 0.5h; Inert atmosphere; Cooling with ice;

methyl iodide; In N,N-dimethyl-formamide; oil;

Reference yield:

: 14432-12-3
4-Amino-2-chloropyridine

: 1415043-77-4
Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 55 °C

2.1: tetrahydrofuran / 1 h / Cooling with ice

3.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice

4.1: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

5.1: acetic anhydride; hydrogen iodide / water / Cooling with ice

5.2: 168 h

6.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.17 h / 20 °C / Cooling with ice; Inert atmosphere

6.2: 5 h / 20 °C

7.1: water; acetic acid / 96 h / 130 °C

7.3: pH 2 - 3

8.1: sulfuric acid / 75 °C

9.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / Inert atmosphere; Cooling with ice

With N-iodo-succinimide; copper(l) iodide; sulfuric acid; water; hydrogen iodide; acetic anhydride; sodium hydride; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; oil;

Reference yield:

: 234108-74-8
(2-chloro-3-iodo-pyridin-4-yl)-carbamic acid tert-butyl ester

: 1415043-77-4
Ethyl {2,5-dimethyl-4-oxo-3-[2-(phenylsulfonyl)benzyl]-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl}acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere; Cooling with acetone-dry ice

2.1: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

3.1: acetic anhydride; hydrogen iodide / water / Cooling with ice

3.2: 168 h

4.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.17 h / 20 °C / Cooling with ice; Inert atmosphere

4.2: 5 h / 20 °C

5.1: water; acetic acid / 96 h / 130 °C

5.3: pH 2 - 3

6.1: sulfuric acid / 75 °C

7.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / Inert atmosphere; Cooling with ice

With copper(l) iodide; sulfuric acid; water; hydrogen iodide; acetic anhydride; sodium hydride; acetic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In water; N,N-dimethyl-formamide; oil;