1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Base Information

• Chemical Name: 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one
• CAS No.: 1309833-20-2
• Molecular Formula: C₁₁H₁₀FN₅O₃
• Molecular Weight: 279.231

Synonyms:1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Chemical Property of 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

Chemical Property:

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Technology Process of 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one

There total 13 articles about 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-1H-tetrazol-5(4H)-one (1309833-22-4) + methyl iodide (74-88-4) → 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one (1309833-20-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at -78 - 20 ℃; for 3h; Inert atmosphere;

Reference yield: 86.0%

potassium cyclopropyltrifluoroborate (1065010-87-8) + 1-(2-bromo-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one (1309831-15-9) → 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one (1309833-20-2)

Guidance literature:

With potassium carbonate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 90 ℃; Inert atmosphere;

Reference yield:

cyclopropylboronic acid methyliminodiacetic acid ester (1104637-36-6) + 1-(2-bromo-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one (1309831-15-9) → 1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one (1309833-20-2)

Guidance literature:

With caesium carbonate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 100 ℃; Inert atmosphere;

upstream raw materials:

2-bromo-4-fluorobenzoyl chloride

1-(2-bromo-4-fluorophenyl)-1,4-dihydro-5H-tetrazol-5-one

1-(2-bromo-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one

2-Cyclopropyl-4-fluoro-5-nitroaniline

Downstream raw materials:

1-(5-amino-2-cyclopropyl-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one

N₂-{4-cyclopropyl-6-fluoro-3-[4-methyl-1,2,3,4-tetrazol-5-one-1-yl]phenyl}-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)-2,4-pyrimidinediamine

2-(4-cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile

1-{2-Cyclopropyl-4-fluoro-5-[5-fluoro-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidin-2-ylamino]-phenyl}-4-methyl-1,4-dihydro-tetrazol-5-one

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