3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

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Chemical Name:3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt
CAS No.:219948-45-5
Molecular Formula:C₁₇H₁₀F₃N₃O
Molecular Weight:329.281
Hs Code.:

Synonyms:3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

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Chemical Property of 3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

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Technology Process of 3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

There total 3 articles about 3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 219948-39-7
4,5-dihydro-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

: 219948-45-5
3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

Guidance literature:: With cyclohexene; palladium on activated charcoal; In N,N-dimethyl acetamide; at 140 ℃; for 48h;
DOI:10.1016/S0040-4020(02)00269-7

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 219948-45-5
3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: conc. HCl; NaNO₂ / H₂O; tetrahydrofuran / 0.25 h / -5 - 0 °C

1.2: H₂O; tetrahydrofuran; pyridine / -5 - 20 °C

1.3: 50 percent / Ac₂O; pyridine / 1 h

2.1: 58 percent / cyclohexene / 10 percent Pd/C / N,N-dimethyl-acetamide / 48 h / 140 °C

With hydrogenchloride; cyclohexene; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl acetamide; water;
DOI:10.1016/S0040-4020(02)00269-7

Reference yield:

: 46185-24-4
1,2,3,4-tetrahydroquinoline-2-carboxylic acid

: 219948-45-5
3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: conc. HCl; NaNO₂ / H₂O; tetrahydrofuran / 0.25 h / -5 - 0 °C

1.2: H₂O; tetrahydrofuran; pyridine / -5 - 20 °C

1.3: 50 percent / Ac₂O; pyridine / 1 h

2.1: 58 percent / cyclohexene / 10 percent Pd/C / N,N-dimethyl-acetamide / 48 h / 140 °C

With hydrogenchloride; cyclohexene; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl acetamide; water;
DOI:10.1016/S0040-4020(02)00269-7