5-bromo-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

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Chemical Name:5-bromo-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt
CAS No.:219948-69-3
Molecular Formula:C₁₇H₉BrF₃N₃O
Molecular Weight:408.177
Hs Code.:

Synonyms:5-bromo-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

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Chemical Property of 5-bromo-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

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Technology Process of 5-bromo-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

There total 2 articles about 5-bromo-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 219948-45-5
3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

: 219948-69-3
5-bromo-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

Guidance literature:: With pyridine; bromine; In dichloromethane;
DOI:10.1016/S0040-4020(02)00269-7

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 219948-69-3
5-bromo-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: conc. HCl; NaNO₂ / H₂O; tetrahydrofuran / 0.25 h / -5 - 0 °C

1.2: H₂O; tetrahydrofuran; pyridine / -5 - 20 °C

1.3: 50 percent / Ac₂O; pyridine / 1 h

2.1: 58 percent / cyclohexene / 10 percent Pd/C / N,N-dimethyl-acetamide / 48 h / 140 °C

3.1: 45 percent / Br₂; pyridine / CH₂Cl₂

With pyridine; hydrogenchloride; bromine; cyclohexene; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1016/S0040-4020(02)00269-7

Reference yield: 19.0%

: 67-56-1
methanol

: 219948-69-3
5-bromo-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

: 5-methoxy-3-oxido-2-[4-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinolinium inner salt

Guidance literature:: With (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 80 ℃; for 14h;
DOI:10.1016/S0040-4020(02)00269-7