tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate

Base Information

Chemical Name:tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate
CAS No.:1349744-47-3
Molecular Formula:C₂₁H₂₄ClFN₂O₅
Molecular Weight:438.883
Hs Code.:

Synonyms:tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate

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Chemical Property of tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate

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Technology Process of tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate

There total 7 articles about tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1349744-45-1
2-(2-chloro-5-methoxy-4-nitrophenyl)-N-(3-fluorobenzyl)ethanamine

: 1349744-47-3
tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1481-68-1
5-chloro-2,4-difluoronitrobenzene

: 1349744-47-3
tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium hydroxide / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

3.1: water; sodium chloride / dimethyl sulfoxide / 2 h / 120 °C

4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

4.2: 0.25 h

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C

6.1: dimethyl sulfoxide / 5 h / 20 °C

7.1: triethylamine / dichloromethane / 1 h / 20 °C

With lithium borohydride; carbon tetrabromide; potassium tert-butylate; water; triethylamine; triphenylphosphine; sodium chloride; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1089280-66-9
1-chloro-2-fluoro-4-methoxy-5-nitrobenzene

: 1349744-47-3
tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

2.1: water; sodium chloride / dimethyl sulfoxide / 2 h / 120 °C

3.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

3.2: 0.25 h

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C

5.1: dimethyl sulfoxide / 5 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 20 °C

With lithium borohydride; carbon tetrabromide; water; triethylamine; triphenylphosphine; sodium chloride; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide;