1089280-66-9

Usage

Uses

Used in Pharmaceutical Industry:
1-chloro-2-fluoro-4-methoxy-5-nitrobenzene is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties. Its unique combination of functional groups allows for targeted modifications and enhancements in drug efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, 1-chloro-2-fluoro-4-methoxy-5-nitrobenzene serves as a key intermediate in the production of agrochemicals, including pesticides and herbicides. Its functional groups enable the creation of compounds that can effectively target and control pests and weeds in agricultural settings.
Used in Dye and Pigment Production:
1-chloro-2-fluoro-4-methoxy-5-nitrobenzene is utilized as a building block in the creation of dyes and pigments, contributing to the development of a wide range of colorants for various applications. Its presence in these compounds allows for the production of vibrant and stable colors.
Used in Specialty Chemicals:
1-chloro-2-fluoro-4-methoxy-5-nitrobenzene also finds use in the production of specialty chemicals, where its unique structure and reactivity are harnessed to create compounds with specific properties for use in various industries, such as plastics, coatings, and textiles.
It is crucial to handle 1-chloro-2-fluoro-4-methoxy-5-nitrobenzene with care due to its potential hazards, and to adhere to proper safety procedures during its use in chemical processes.

Upstream product

• 501-29-1 1-chloro-2-fluoro-4-methoxybenzene 
• 67-56-1 methanol 
• 1481-68-1 5-chloro-2,4-difluoronitrobenzene 
• 345-25-5 4-chloro-5-fluoro-2-nitrophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 1089280-67-0 1'-[2-chloro-5-(methyloxy)-4-nitrophenyl]-1,4'-bipiperidine 
• 1349744-41-7 2-(2-chloro-5-methoxy-4-nitrophenyl)acetic acid methyl ester 
• 1349744-42-8 2-(2-chloro-5-methoxy-4-nitrophenyl)ethanol 
• 1349744-43-9 1-(2-bromoethyl)-2-chloro-5-methoxy-4-nitrobenzene 
• 1349744-45-1 2-(2-chloro-5-methoxy-4-nitrophenyl)-N-(3-fluorobenzyl)ethanamine 
• 1349744-47-3 tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl-(3-fluorobenzyl)-carbamate 
• 1349744-48-4 tert-butyl (4-amino-2-chloro-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate 
• 1349744-49-5 tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate 
• 1349744-66-6 2-(2-chloro-5-methoxy-4-nitrophenyl)-N-(4-fluorobenzyl)ethanamine 
• 1349744-68-8 tert-butyl (2-chloro-5-methoxy-4-nitrophenyl)ethyl(4-fluorobenzyl)carbamate 
• 1349744-69-9 tert-butyl (4-amino-2-chloro-5-methoxyphenyl)ethyl(4-fluorobenzyl)carbamate 
• 1349744-72-4 tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(4-fluorobenzyl)carbamate 
• 1394839-94-1 5-chloro-4-fluoro-2-methoxyaniline 

Relevant academic research and scientific papers

SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS

Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammatory diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also disc

NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF- KB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

Spiro aryl phosphorus oxide or sulfide

The invention discloses a spiro aryl phosphorus oxide or sulfide as ALK inhibitor, and in particular discloses a compound shown in a formula (I) as an ALK inhibitor or a pharmaceutically acceptable salt thereof.

7-HYDROXY-SPIROPIPIPERIDINE INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of Ρ2Y1 receptor and may be used as medicaments in the treatment and/or prophylaxis of thromboembolic disorders.

PHARMACEUTICAL COMPOUNDS

The invention provides a compound of the formula (1): or a salt, N-oxide or tautomer thereof; wherein R1 is cyano or C1-4 alkyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 and R5 are the same or different and each is selected from hydrogen, saturated C1-4 hydrocarbyl and saturated C1-4 hydrocarbyloxy; R6 and R7 are the same or different and each is selected from hydrogen, halogen, CN, C1-4 alkyl and C1-4 alkoxy wherein the C1-4 alkyl and C1-4 alkoxy are each optionally substituted with hydroxy, C1-2 alkoxy or by one or more flourine atoms; R8 is hydrogen or C1-4 alkyl; Q is an alkylene chain of 1 to 4 carbon atoms in length between the moiety Ar and the nitrogen atom N, wherein one or more of the 1 to 4 carbon atoms of the alkylene chain may optionally be substituted with one or two C1-4 alkyl groups, or wherein one carbon atom of the 1 to 4 carbon atoms of the alkylene chain may optionally be substituted with a group -CH2CH2- which together with the said one carbon atom forms a cyclopropyl group; m is 1, 2, 3 or 4; n is 0 or 1; and Ar is a monocyclic or bicyclic aryl or heteroaryl group of 5 to 10 ring members containing 0, 1, 2, 3 or 4 heteroatom ring members selected from O, N and S, the aryl or heteroaryl group being optionally substituted with one to four substituents R13 as defined in the claims. The compounds are inhibitors of Chk-1 kinase and are active against cancers.

Imidazopyridine Kinase Inhibitors

The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.