10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one

Base Information

• Chemical Name: 10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one
• CAS No.: 1100269-63-3
• Molecular Formula: C₁₉H₁₈N₂O₄
• Molecular Weight: 338.363

Synonyms:10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one

Chemical Property of 10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one

Chemical Property:

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Technology Process of 10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one

There total 2 articles about 10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

3,4-dimethoxy-benzaldehyde (120-14-9) + 4-(2-aminoanilino)-2,5-dihydro-2-furanone (486403-42-3) → 10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one (1100269-63-3)

Guidance literature:

With acetic acid; In butan-1-ol; for 3h; Heating;

DOI:10.1007/s11172-007-0363-y

Reference yield:

1,2-diamino-benzene (95-54-5) → 10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one (1100269-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / 10 h / 20 °C

2: acetic acid / chloroform / 0.5 h / Microwave irradiation

With acetic acid; In ethanol; chloroform;

DOI:10.1016/j.bioorg.2018.07.023

Reference yield: 96.5%

10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-benzo[b]furo[3,4-e][1,4]diazepin-1-one (1100269-63-3) + chloroacetyl chloride (79-04-9) → 9-(2-chloroacetyl)-10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-furo[3,4-b][1,5]benzodiazepin-1-one (1100269-66-6)

Guidance literature:

In benzene; for 3h; Heating;

DOI:10.1007/s11172-007-0363-y

upstream raw materials:

3,4-dimethoxy-benzaldehyde

4-(2-aminoanilino)-2,5-dihydro-2-furanone

1,2-diamino-benzene

Downstream raw materials:

9-(2-chloroacetyl)-10-(3,4-dimethoxyphenyl)-3,4,9,10-tetrahydro-1H-furo[3,4-b][1,5]benzodiazepin-1-one

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