C₃₀H₂₈F₄O₂

Base Information

• Chemical Name: C₃₀H₂₈F₄O₂
• CAS No.: 221342-61-6
• Molecular Formula: C₃₀H₂₈F₄O₂
• Molecular Weight: 496.545
• Mol file: 221342-61-6.mol

Synonyms:C₃₀H₂₈F₄O₂

Chemical Property of C₃₀H₂₈F₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₂₈F₄O₂

There total 10 articles about C₃₀H₂₈F₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C30H26F4O2 (221342-60-5) → C30H28F4O2 (221342-61-6)

Guidance literature:

With (1R,2S)-1-Amino-2-indanol; borane; N,N-diethylaniline; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/(SICI)1521-3773(19991115)38:22<3373::AID-ANIE3373>3.0.CO;2-F

Reference yield:

spiro[3.5]nonane-6,8-dione (221342-48-9) → C30H28F4O2 (221342-61-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: isobutanol; p-TsOH / toluene / Heating

1.2: 77 percent / RedAl / toluene / 40 - 50 °C

2.1: 42 percent / TiCl₄; Ti(i-PrO)4 / CH₂Cl₂ / 2.17 h / -7 - 20 °C

3.1: SOCl₂; pyridine / 0 °C

3.2: NCS; (PhCO₂)2 / CH₂Cl₂ / 20 °C

3.3: DBU / dioxane / 96 °C

4.1: 78 percent / (1R,2S)-1-aminoindan-2-ol; BH₃; PhNEt₂ / tetrahydrofuran / 20 °C

With pyridine; titanium(IV) isopropylate; thionyl chloride; 2-methyl-propan-1-ol; (1R,2S)-1-Amino-2-indanol; borane; titanium tetrachloride; toluene-4-sulfonic acid; N,N-diethylaniline; In tetrahydrofuran; dichloromethane; toluene; 1.1: Etherification / 1.2: Reduction / 2.1: Cyclization / 3.1: Dehydration / 3.2: Chlorination / 3.3: Aromatisation / 4.1: Reduction;

DOI:10.1002/(SICI)1521-3773(19991115)38:22<3373::AID-ANIE3373>3.0.CO;2-F

Reference yield:

2-(trimethylsilyloxy)-3-methyl-1-butene (17510-45-1) → C30H28F4O2 (221342-61-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: TiCl₄; Ti(OiPr)4 / CH₂Cl₂

1.2: 65 percent / CH₂Cl₂

2.1: SOCl₂; pyridine

2.2: NCS; (PhCO₂)2 / CH₂Cl₂

2.3: DBU; air / dioxane

3.1: BH₃*Et₂NPh; (1R,2S)-1-aminoindanol

With pyridine; titanium(IV) isopropylate; borane N,N-diethylaniline complex; thionyl chloride; (1R,2S)-1-Amino-2-indanol; titanium tetrachloride; In dichloromethane; 1.1: Mukaiyama-Michael addition / 1.2: Michael addition;

DOI:10.2533/000942904777678082

upstream raw materials:

C₃₀H₂₆F₄O₂

2-(trimethylsilyloxy)-3-methyl-1-butene

spiro[3.5]non-7-en-6-one

1-(4-fluorophenyl)-3-(4-trifluoromethylphenyl)-propen-3-one

Downstream raw materials:

C₃₆H₄₂F₄O₂Si

C₃₆H₄₃F₅OSi

C₃₆H₄₄F₄O₂Si

C₃₆H₄₄F₄O₂Si