7-(8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Base Information

Chemical Name:7-(8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid
CAS No.:1356332-03-0
Molecular Formula:C₂₈H₃₃N₃O₃
Molecular Weight:459.588
Hs Code.:

Synonyms:7-(8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Chemical Property of 7-(8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Technology Process of 7-(8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

There total 11 articles about 7-(8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356333-04-4
ethyl 7-(8-acetoxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate

: 1356332-03-0
7-(8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: ethyl 7-(8-acetoxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate; With sodium hydroxide; In ethanol; at 20 ℃; for 18h;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 67-56-1
methanol

: 3990-05-4
ethyl 6-formylhexanoate

: 1356332-65-4
2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

: 1356332-03-0
7-(8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

: 1447304-90-6
7‐[8‐methoxy‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoic acid

Guidance literature:: ethyl 6-formylhexanoate; 2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

methanol;

With water; sodium hydroxide; In ethanol; at 20 ℃; Inert atmosphere;

Reference yield:

: 452-58-4
2,3-Diaminopyridine

: 1356332-03-0
7-(8-hydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: ethanol / 1.5 h / 85 °C

2: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 20 °C / 75.01 Torr

3: dmap / tetrahydrofuran / 48 h / 20 °C

4: N-Bromosuccinimide / dilauryl peroxide / chloroform / 1 h / Reflux

5: dichloromethane / 0.5 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

7: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

8: sodium hydroxide / ethanol / 18 h / 20 °C

With N-Bromosuccinimide; hydrogen; sodium tris(acetoxy)borohydride; trifluoroacetic acid; sodium hydroxide; dmap; dilauryl peroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; chloroform; 1,2-dichloro-ethane;