2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol

Base Information

• Chemical Name: 2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol
• CAS No.: 917572-33-9
• Molecular Formula: C₂₂H₂₈N₂O₂
• Molecular Weight: 352.477
• Mol file: 917572-33-9.mol

Synonyms:2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol

Chemical Property of 2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol

There total 6 articles about 2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-benzhydryl 3-azetidinone (40320-60-3) + 2-[(3R)-morpholin-3-yl]ethanol (917572-32-8,399580-64-4) → 2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol (917572-33-9)

Guidance literature:

N-benzhydryl 3-azetidinone; 2-[(3R)-morpholin-3-yl]ethanol; With (polystyrylmethyl)trimethylammonium cyanoborohydride; acetic acid; In methanol; at 120 ℃; for 0.0833333h; Polystyrene Microwave irradiation;

With water; sodium hydrogencarbonate;

Reference yield:

(S)-4-benzyl-3-(chloromethyl)morpholine (917572-28-2) → 2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol (917572-33-9)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 h / Heating / reflux

2: hydrogenchloride / 20 °C

3: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

4: hydrogen; acetic acid / palladium(II) hydroxide/carbon / 17 h / 20 °C / 3000.3 Torr

5: (polystyrylmethyl)trimethylammonium cyanoborohydride; acetic acid / methanol / 0.08 h / 120 °C / Microwave irradiation

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; (polystyrylmethyl)trimethylammonium cyanoborohydride; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; palladium(II) hydroxide/carbon; In methanol; diethyl ether; dichloromethane; water;

Reference yield:

(R)-2-(4-benzylmorpholin-3-yl)acetonitrile (917572-29-3,1217855-96-3,170701-93-6) → 2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol (917572-33-9)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / 20 °C

2: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

3: hydrogen; acetic acid / palladium(II) hydroxide/carbon / 17 h / 20 °C / 3000.3 Torr

4: (polystyrylmethyl)trimethylammonium cyanoborohydride; acetic acid / methanol / 0.08 h / 120 °C / Microwave irradiation

With hydrogenchloride; lithium aluminium tetrahydride; (polystyrylmethyl)trimethylammonium cyanoborohydride; hydrogen; acetic acid; palladium(II) hydroxide/carbon; In methanol; diethyl ether;

upstream raw materials:

N-benzhydryl 3-azetidinone

2-[(3R)-morpholin-3-yl]ethanol

(S)-4-benzyl-3-(chloromethyl)morpholine

(R)-2-(4-benzylmorpholin-3-yl)acetonitrile