(R)-2-(morpholin-3-yl)ethanol

Base Information

• Chemical Name: (R)-2-(morpholin-3-yl)ethanol
• CAS No.: 917572-32-8
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• DSSTox Substance ID: DTXSID20703889
• Wikidata: Q72492896
• Mol file: 917572-32-8.mol

Synonyms:917572-32-8;(R)-2-(morpholin-3-yl)ethanol;(R)-3-HYDROXYETHYLMORPHOLINE;2-[(3R)-morpholin-3-yl]ethanol;3-Morpholineethanol, (3R)-;(R)-2-(morpholin-3-yl)ethan-1-ol;2-[(3R)-Morpholin-3-yl]ethan-1-ol;3-Morpholineethanol,(3R)-;SCHEMBL3225663;AMY1958;DTXSID20703889;TVPDWWYLCZDJKD-ZCFIWIBFSA-N;AKOS006324717;CS-0199961;EN300-2987075

Chemical Property of (R)-2-(morpholin-3-yl)ethanol

Chemical Property:

• Vapor Pressure: 0.00248mmHg at 25°C
• Refractive Index: 1.445
• Boiling Point: 255.4 °C at 760 mmHg
• Flash Point: 108.2 °C
• PSA: 41.49000
• Density: 1.019 g/cm³
• LogP: -0.31400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 77.5

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-(Morpholin-3-yl)ethanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCC(N1)CCO
• Isomeric SMILES: C1COC[C@H](N1)CCO

Technology Process of (R)-2-(morpholin-3-yl)ethanol

There total 5 articles about (R)-2-(morpholin-3-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-[(3R)-4-benzylmorpholin-3-yl]ethanol (917572-31-7) → 2-[(3R)-morpholin-3-yl]ethanol (917572-32-8,399580-64-4)

Guidance literature:

2-[(3R)-4-benzylmorpholin-3-yl]ethanol; With hydrogen; acetic acid; palladium(II) hydroxide/carbon; at 20 ℃; for 17h; under 3000.3 Torr;

With ammonia; In methanol;

Reference yield:

(S)-4-benzyl-3-(chloromethyl)morpholine (917572-28-2) → 2-[(3R)-morpholin-3-yl]ethanol (917572-32-8,399580-64-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 h / Heating / reflux

2: hydrogenchloride / 20 °C

3: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

4: hydrogen; acetic acid / palladium(II) hydroxide/carbon / 17 h / 20 °C / 3000.3 Torr

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; palladium(II) hydroxide/carbon; In diethyl ether; dichloromethane; water;

Reference yield:

(R)-2-(4-benzylmorpholin-3-yl)acetonitrile (917572-29-3,1217855-96-3,170701-93-6) → 2-[(3R)-morpholin-3-yl]ethanol (917572-32-8,399580-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 20 °C

2: lithium aluminium tetrahydride / diethyl ether / 1 h / 20 °C

3: hydrogen; acetic acid / palladium(II) hydroxide/carbon / 17 h / 20 °C / 3000.3 Torr

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; acetic acid; palladium(II) hydroxide/carbon; In diethyl ether;

upstream raw materials:

2-[(3R)-4-benzylmorpholin-3-yl]ethanol

(S)-4-benzyl-3-(chloromethyl)morpholine

(R)-2-(4-benzylmorpholin-3-yl)acetonitrile

methyl [(3R)-4-benzylmorpholin-3-yl]acetate

Downstream raw materials:

2-{(3R)-4-[1-(diphenylmethyl)azetidin-3-yl]morpholin-3-yl}ethanol

Refernces