N-4-nitrobenzenesulfonyl-3-methylphenethylamine

Base Information

• Chemical Name: N-4-nitrobenzenesulfonyl-3-methylphenethylamine
• CAS No.: 859163-15-8
• Molecular Formula: C₁₅H₁₆N₂O₄S
• Molecular Weight: 320.369
• Mol file: 859163-15-8.mol

Synonyms:N-4-nitrobenzenesulfonyl-3-methylphenethylamine

Chemical Property of N-4-nitrobenzenesulfonyl-3-methylphenethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-4-nitrobenzenesulfonyl-3-methylphenethylamine

There total 3 articles about N-4-nitrobenzenesulfonyl-3-methylphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-(3-methylphenyl)ethylamine (55755-17-4) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → N-4-nitrobenzenesulfonyl-3-methylphenethylamine (859163-15-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/jo050503t

Reference yield:

1-methyl-3-(2-nitrovinyl)benzene (22568-43-0,62248-93-5) → N-4-nitrobenzenesulfonyl-3-methylphenethylamine (859163-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.2 g / LiAlH₄ / tetrahydrofuran / 3 h / Heating

2: 58 percent / Et₃N / CH₂Cl₂ / 6 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo050503t

Reference yield:

m-tolyl aldehyde (620-23-5) → N-4-nitrobenzenesulfonyl-3-methylphenethylamine (859163-15-8)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / 2 h / Heating

2: 2.2 g / LiAlH₄ / tetrahydrofuran / 3 h / Heating

3: 58 percent / Et₃N / CH₂Cl₂ / 6 h / 20 °C

With ammonium acetate; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo050503t

upstream raw materials:

2-(3-methylphenyl)ethylamine

4-Nitrobenzenesulfonyl chloride

1-methyl-3-(2-nitrovinyl)benzene

m-tolyl aldehyde

Downstream raw materials:

N-(1-benzyloxyallyl)-N-4-nitrobenzenesulfonyl-3-methylphenethylamine

Refernces