(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-octanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

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Chemical Name:(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-octanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester
CAS No.:148432-30-8
Molecular Formula:C₄₁H₆₄N₂O₆
Molecular Weight:680.969
Hs Code.:

Synonyms:(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-octanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

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Chemical Property of (R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-octanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

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Technology Process of (R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-octanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

There total 5 articles about (R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-octanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3587-60-8
Benzyloxymethyl chloride

: 148432-22-8
(S,R)-(+)-1-[3-Hydroxy-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-heptylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine

: 148432-30-8
(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-octanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 15h; Heating;

Reference yield:

: 110-62-3
pentanal

: 148432-30-8
(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-octanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LDA, LiBr / 1) THF, hexane, -78 deg C, 1-2 h, 2) THF, a) 1-2 h, -90 deg C, b) -78 deg C, 1 h

2: 93 percent / nBu₄NI, iPr₂NEt / CH₂Cl₂ / 15 h / Heating

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; lithium bromide; lithium diisopropyl amide; In dichloromethane;

Reference yield:

: 118535-62-9
(S)-(-)-1-amino-2-(1'-methoxy-1'-ethylpropyl)pyrrolidine

: 148432-30-8
(R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-octanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / cyclohexane

2: 1) LDA, LiBr / 1) THF, hexane, -78 deg C, 1-2 h, 2) THF, a) 1-2 h, -90 deg C, b) -78 deg C, 1 h

3: 93 percent / nBu₄NI, iPr₂NEt / CH₂Cl₂ / 15 h / Heating

With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; lithium bromide; lithium diisopropyl amide; In dichloromethane; cyclohexane;