2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

Base Information

• Chemical Name: 2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile
• CAS No.: 1048034-90-7
• Molecular Formula: C₁₉H₂₁ClN₄O₄S
• Molecular Weight: 436.919
• Mol file: 1048034-90-7.mol

Synonyms:2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

Chemical Property of 2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

There total 6 articles about 2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2-bromo-2-(2-ethyl)dioxolane (18742-02-4) + 2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile (1048034-83-8) → 2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile (1048034-90-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 108h;

Reference yield:

3-Cyano-4-chloro-benzoic acid (117738-76-8) → 2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile (1048034-90-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h

2.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

2.2: 18 h / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

With oxalyl dichloride; caesium carbonate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

C11H20N2O2S (1048034-93-0) → 2-chloro-5-[1-(2-[1,3]dioxolan-2-yl-ethyl)-5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile (1048034-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

1.2: 18 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

With caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-bromo-2-(2-ethyl)dioxolane

2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

C₁₁H₂₀N₂O₂S

4-piperidone hydrochloride

Downstream raw materials:

C₂₁H₂₇ClN₄O₃S

2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

(2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-phenyl)-methanol

2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine