-1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone

Base Information

Chemical Name:-1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone
CAS No.:150026-73-6
Molecular Formula:C₂₈H₂₄ClNO₂
Molecular Weight:441.957
Hs Code.:

<R-(E)>-1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone

Synonyms:-1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone

Suppliers and Price of -1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of -1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

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Hazard Codes:

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Technology Process of -1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone

There total 6 articles about -1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 150026-72-5
-2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>benzoic acid methyl ester

: 150026-73-6
-1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone

Guidance literature:: methylmagnesium chloride; With lithium hexamethyldisilazane; In hexane; at -5 - 0 ℃; for 0.75h;

-2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>benzoic acid methyl ester; In tetrahydrofuran; hexane; at -5 - 0 ℃; for 5.5h;

Reference yield:

: 120578-03-2
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde

: 150026-73-6
-1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / toluene; tetrahydrofuran / 1 h / 0 - 5 °C

2: 83 percent / Et₃N / Pd(OAc)2 / acetonitrile / 12 h / Heating

3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h

4: 1) lithium hexamethyldisilazide / 1) THF, 2) toluene, 0 deg C, 1 h

With chloroborane-methyl sulfide; 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium diacetate; In tetrahydrofuran; hexane; toluene; acetonitrile;
DOI:10.1021/jo00066a027

Reference yield:

: 610-97-9
o-iodo-methyl-benzoic acid

: 150026-73-6
-1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / Et₃N / Pd(OAc)2 / acetonitrile / 12 h / Heating

2: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h

3: 1) lithium hexamethyldisilazide / 1) THF, 2) toluene, 0 deg C, 1 h

With chloroborane-methyl sulfide; 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium diacetate; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/jo00066a027