ethyl 2-ethyl-3-[3-[4-(trifluoromethyl)benzoylaminomethyl]-4-methoxyphenyl]propanoate

Base Information

Chemical Name:ethyl 2-ethyl-3-[3-[4-(trifluoromethyl)benzoylaminomethyl]-4-methoxyphenyl]propanoate
CAS No.:334015-34-8
Molecular Formula:C₂₃H₂₆F₃NO₄
Molecular Weight:437.459
Hs Code.:

Synonyms:ethyl 2-ethyl-3-[3-[4-(trifluoromethyl)benzoylaminomethyl]-4-methoxyphenyl]propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-ethyl-3-[3-[4-(trifluoromethyl)benzoylaminomethyl]-4-methoxyphenyl]propanoate

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Technology Process of ethyl 2-ethyl-3-[3-[4-(trifluoromethyl)benzoylaminomethyl]-4-methoxyphenyl]propanoate

There total 11 articles about ethyl 2-ethyl-3-[3-[4-(trifluoromethyl)benzoylaminomethyl]-4-methoxyphenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1891-90-3
p-trifluoromethylbenzamide

: 378232-23-6
ethyl 2-ethyl-3-(3-formyl-4-methoxyphenyl)propanoate

: 334015-34-8
ethyl 2-ethyl-3-[3-[4-(trifluoromethyl)benzoylaminomethyl]-4-methoxyphenyl]propanoate

Guidance literature:: With triethylsilane; trifluoroacetic acid; In toluene; for 24h; Heating;
DOI:10.1016/j.bmc.2007.05.023

Reference yield:

: 455-24-3
4-trifluoromethylbenzoic acid

: 541-41-3
chloroformic acid ethyl ester

: ethyl 3-[3-(aminomethyl)-4-methoxyphenyl]-2-ethylpropanoate hydrochloride

: 334015-34-8
ethyl 2-ethyl-3-[3-[4-(trifluoromethyl)benzoylaminomethyl]-4-methoxyphenyl]propanoate

Guidance literature:: With sodium hydrogencarbonate; triethylamine; In dichloromethane;

Reference yield:

: 17145-91-4
triethyl 2-ethylphosphonoacetate

: 334015-34-8
ethyl 2-ethyl-3-[3-[4-(trifluoromethyl)benzoylaminomethyl]-4-methoxyphenyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran / 1 h

1.2: tetrahydrofuran / 4 h / 0 - 20 °C

2.1: H₂ / Pd/C / tetrahydrofuran; ethanol / 2192.43 Torr

3.1: TiCl₄ / CH₂Cl₂ / 6 h / -20 °C

3.2: 97 percent / aq. HCl / CH₂Cl₂

4.1: 89 percent / NH₂OH*HCl; pyridine / ethanol / 6 h / Heating

5.1: H₂ / Pd/C / tetrahydrofuran; ethanol / 2207.43 Torr

6.1: CH₂Cl₂ / -10 - 20 °C

With pyridine; hydroxylamine hydrochloride; hydrogen; titanium tetrachloride; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm0205144